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Pre-Colonization and Native American HistoryMap of portion of the Trail of Tears showing Cherokee removal routes. The area now known as Tennessee was first settled by Paleo-Indians nearly 11,000 years ago. The names of the cultural groups that inhabited the area between first settlement and the time of European contact are unknown, but several distinct cultural phases have been named by archaeologists, including Archaic, Woodland, and Mississippian whose chiefdoms were the cultural predecessors of the Muscogee people who inhabited the Tennessee River Valley prior to Cherokee migration into the river's headwaters. When Spanish explorers first visited Tennessee, led by Hernando de Soto in 1539–43, it was inhabited by tribes of Muscogee and Yuchi people. Possibly because of European diseases devastating the Native tribes, which would have left a population vacuum, and also from expanding European settlement in the north, the Cherokee moved south from the area now called Virginia. As European colonists spread into the area, the native populations were forcibly displaced to the south and west, including all Muscogee and Yuchi peoples, the Chickasaw, and Choctaw. From 1838 to 1839, nearly 17,000 Cherokees were forced to march from "emigration depots" in Eastern Tennessee, such as Fort Cass, to Indian Territory west of Arkansas. This came to be known as the Trail of Tears, as an estimated 4,000 Cherokees died along the way. ColonizationThe Transylvania Purchase, bought from the Cherokee tribe, stretches from Sycamore Shoals in Elizabethton, Tennessee to the Wilderness Road into Kentucky. The area around Clarksville was first surveyed by Thomas Hutchins in 1768.